by Col. Lawrence Sellin (Ret.)
(scientific references in parentheses)
Since the onset of the pandemic, the Chinese Communist Party, together with the support or acquiescence of the majority of the Western scientific community, have insisted that the COVID-19 virus was a naturally-occurring, animal-to-human transmission.
Despite exhaustive international research efforts, a natural source for the COVID-19 virus, whether directly from bats to humans or through an intermediate animal host, has not been identified.
That is, there is still no convincing scientific evidence that the COVID-19 virus originated from any natural source, whereas the evidence for a laboratory origin is extensive and increasing.
In the end, it is simply a matter of whether you want to believe a narrative shaped by those with vested interests or you want to believe the facts.
The genetic engineering and related laboratory techniques to manufacture a virus like COVID-19 have existed for more than 20 years.
Over time, those techniques have only become more sophisticated, such that it is now impossible to distinguish between a natural and a man-made virus.
The COVID-19 virus has a number of unique structural features that cannot be explained as products of a natural evolutionary process.
Those anomalies primarily affect the COVID-19 virus’ extraordinarily high infectivity rate of +100,000,000 compared to, for example, the 8,096 in the first 2002-2004 SARS pandemic.
That increase in infectivity is directly related to the enhanced ability of the COVID-19 virus to bind to and enter human cells, both of which can be achieved by laboratory manipulation.
The COVID-19 virus binds to human cells 10-20 times better than the 2002-2004 SARS virus (1,2).
From the beginning, the COVID-19 virus appeared to be well-adapted (3,4) even pre-adapted (5) for binding to human cells.
The COVID-19 virus did not undergo the same mutation and adaptation to humans over time as did the 2002-2004 SARS virus, but was already, from the beginning, resembling late-stage SARS infections, suggesting pre-adaptation (5).
Such pre-adaption for human infection can be accomplished in the laboratory by repeatedly exposing coronaviruses to genetically-engineered mice that have the human receptor, a process known as serial passage.
Since 2007, Chinese scientists have used humanized mouse models to experiment with coronaviruses starting with the 2002-2004 SARS virus (6).
The second unique feature of the COVID-19 virus affecting infectivity is the presence of a furin polybasic cleavage site, a structure that facilitates membrane fusion between the virus and human cells.
The furin polybasic cleavage site is essential for human infection (7) and is a structure known by Chinese scientists to also enhance pathogenicity (8), but a structure not found in any bat coronaviruses closely related to the COVID-19 virus (7).
The unique COVID-19 virus polybasic cleavage site insertion is a short sequence of the amino acids, proline-arginine-arginine-alanine or “PRRA.”
The combination of genomic nucleotides that codes for the two joint arginines (RR), a double cytosine-guanine-guanine or CGG-CGG sequence is extremely rare, being the only instance of it in the entire COVID-19 viral genome (9).
In addition, the presence of the structurally rigid amino acid proline in the PRRA insert is also unusual. It causes the furin polybasic cleavage site to protrude from the surrounding structure making it more accessible to the enzymes on the human cell surface, thereby facilitating virus entry.
Coupled with the surrounding structure, insertion of a rigid proline could increase antigenicity, making vaccine development easier, but such a feature is not advantageous to a virus undergoing natural evolution.
In 2004, at the end of the first SARS pandemic, a U.S. patent, entitled “Inserton of Furin Protease Cleavage Sites in Membrane Proteins and Uses Thereof” was filed describing how furin polybasic cleavage sites could be artificially inserted into viruses.
During the 17 years since that patent was filed, it has only been cited 23 times, one of which was by Chinese People’s Liberation Army-trained scientists Shibo Jiang and Shuwen Liu, who, in 2013, were artificially inserting furin polybasic cleavage sites in experiments involving viruses (10).
Shibo Jiang, Shuwen Liu and their Chinese colleagues, many of whom have connections to the People’s Liberation Army and the Wuhan Institute of Virology, would become major players in the coronavirus research leading up to the COVID-19 pandemic.
I have only provided the most obvious anomalies, but there are far more examples indicating that the COVID-19 virus was created in a laboratory.
After the first SARS pandemic,…
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