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August 12, 2020 at 4:35 pm

THREAD: Growing Evidence T-Cell Immunity Allows Populations to Reach Herd Immunity by James Todaro, MD…

T_cell_immunity_coronavirus
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1/ There is growing evidence that T-cell immunity allows populations to reach herd immunity once only 10-20% are infected with SARS-CoV-2.

This would explain why a highly transmissible virus in densely populated areas peaked at 10-20% infected regardless of lockdowns or masks.

2/ The pervasive misconception is that we have zero immunity against COVID-19. Based on this flawed understanding, epidemiologists projected that herd immunity is not reached until 60-70% are infected.

This is almost certainly wrong.

Of course, the media ignores this research

3/ While antibodies against COVID-19 may only last months, T cell immunity can remain protective for years.

In a study of 23 people who survived SARS in 2003, every single one had memory T cells that recognized the SARS virus 17 years later. (Nature)

nature.com/articles/s4158…

4/ Moreover, blood samples from all 23 individuals showed “robust cross-reactivity” against SARS-CoV-2.

This can be called crossover immunity.

Crossover immunity is not limited to just people who were infected with SARS years ago though.

5/ In the same study, in 37 persons with no history of SARS or COVID-19 (negative serology and/or samples taken before COVID-19), over 50% had SARS-CoV-2 specific T cells.

This is not surprising because there are at least 4 strains of coronaviruses that cause the “common cold”.

6/ The above study is not the only one to show this level of cross-reactivity.

In a study from April 2020, in 68 healthy donors never exposed to COVID-19, 34% had T cells that reacted to SARS-CoV-2.

medrxiv.org/content/10.110…

7/ This finding was confirmed in yet another study published in Cell in June 2020 showing that 40-60% of unexposed individuals had T cell recognition of SARS-CoV-2.

The authors hypothesized that crossover immunity came from “common cold” coronaviruses.

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development, interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and… https://www.sciencedirect.com/science/article/pii/S0092867420306103?via%3Dihub

 

8/ Crossover immunity may explain why so many young and middle-aged individuals are asymptomatic even when testing positive for coronavirus.

It is likely that their T cells recognized the virus and mounted an immune response before even mild symptoms surfaced.

9/ What does this mean?

All those runny noses from the common cold prepared our T cells to fight COVID-19.

Although it has been ominously called the “novel-coronavirus”, SARS-CoV-2 is yet another coronavirus with many similarities in structure to the common cold coronaviruses.

10/ Why are the elderly hit so hard by COVID-19 though?

Indeed the strain of coronavirus that we faced in 2020 is more lethal than those in the past, specifically in the elderly and immunocompromised…

11/ …With an understanding of T cell immunity, it makes sense that the elderly are more affected by COVID-19.

It is well known that persons in advanced age and/or who are immunocompromised lose T cells.

T cell immunity in the elderly A study by Monash Biomedicine Discovery Institute (BDI) expands the understanding of the molecular pathways that control T cell function and survival and how it relates to declining T cell immunity i… https://medicalxpress.com/news/2020-06-cell-immunity-elderly.html

 

 
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