by Robert W Malone MD, MS
Immune imprinting, breadth of variant recognition and germinal center response in human SARS-CoV-2 infection and vaccination Cell. Published:January 24, 2022DOI:https://doi.org/10.1016/j.cell.2022.01.018
Highlights (per the journal)
- Vaccination confers broader IgG binding of variant RBDs than SARS-CoV-2 infection
- Imprinting from initial antigen exposures alters IgG responses to viral variants
- Histology of mRNA vaccinee lymph nodes shows abundant germinal centers
- Vaccine spike antigen and mRNA persist for weeks in lymph node germinal centers
The hidden highlight (lede) buried in this peer reviewed paper is that protein production of spike in people vaccinated with the Moderna or Pfizer vaccine is higher than those of severely ill COVID-19 patients! A person might ask, “How could that be?” In order to understand this, we must carefully analyze what the study shows.
This study asserts that the mRNA and the spike protein produced persists for weeks in lymph node germinal centers in human patients. Having worked with mRNA for decades, I can attest that this is highly unusual.
One very real hypothesis is that the substitution of pseudouridine for uridine to avoid the immune response is working so well that the mRNA is completely evading the normal clearance/degradation pathways. Hence, mRNA that is not being incorporated into cells at the injection site, is migrating to the lymph nodes (and throughout the body as the non-clinical Pfizer data suggest?) and continuing to express protein there. In this case, the cytotoxic protein antigen is spike. Spike protein can be detected for at least 60 days after administration of dose. Note that the duration of the protein expression was only tested for 60 days.
The spike protein, let’s review what it is and how it is being used (from the Daily Skeptic):…
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